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Target intelligence / Profile preview
Receptor-type tyrosine-protein phosphatase C (CD45)
- Target
- CD45
- Molecular classification
- Receptor, Enzyme, Protein tyrosine phosphatase
01
Overview
CD45RC is an isoform of the protein tyrosine phosphatase receptor type C (PTPRC), also known as CD45 or leukocyte common antigen (LCA). It is a type I transmembrane glycoprotein expressed on all nucleated hematopoietic cells except erythrocytes and plasma cells. CD45RC plays a crucial role in regulating immune signaling by controlling phosphorylation states through its tyrosine phosphatase activity, essential for T-cell and B-cell activation. Its expression pattern helps distinguish immune cell subsets and is implicated in immunodeficiency and autoimmune diseases.
- Other names
- CD45Leukocyte Common Antigen (LCA)PTPRCRPTPRCCD45RC
02
Mechanism of action
Dephosphorylation of tyrosine residues on target proteins
03
Biological functions
Signal transductionImmune responseT-cell activationB-cell activationRegulation of phosphorylation
04
Disease associations
Immunodeficiency syndromesAutoimmunityMultiple sclerosis
05
Biomarkers
CD45RC expression levels for immune cell subset identificationNaive/memory/effector lymphocyte differentiation
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