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Target intelligence / Profile preview
Receptor-type tyrosine-protein phosphatase epsilon (PTPRE)
- Target
- PTPRE
- Molecular classification
- Enzyme, Receptor, Protein tyrosine phosphatase (receptor type)
01
Overview
Receptor-type tyrosine-protein phosphatase epsilon (PTPRE) is a member of the protein tyrosine phosphatase (PTP) family, acting as a signaling molecule involved in the regulation of various cellular processes such as cell growth, differentiation, the mitotic cycle, and oncogenic transformation. PTPRE exists in at least two isoforms: one as a receptor-type PTP with a short extracellular domain, transmembrane region, and tandem intracytoplasmic catalytic domains, and another as a nonreceptor-type isoform with a distinct N-terminus. Both forms function as negative regulators of FceRI-mediated signaling, influence cytokine production and degranulation, and have roles in RAS/MAPK signaling, insulin receptor signaling, and potassium channel activation. PTPRE has been studied as a potential biomarker for early detection of certain cancers, including triple-negative breast cancer[1][2][6].
- Other names
- Protein-tyrosine phosphatase epsilonR-PTP-epsilonR-PTP-EPSILONHPTPEPTPEprotein tyrosine phosphatase, receptor type, Eprotein tyrosine phosphatase, receptor type, epsilon polypeptideEC 3.1.3.48
02
Biological functions
Signal transductionRegulation of cell growthDifferentiationCell cycle (mitotic cycle)Regulation of cytokine productionRegulation of degranulationRegulation of RAS-mediated signaling pathwaysInsulin receptor signaling regulationActivation of voltage-gated potassium channels
03
Disease associations
Cancer (notably breast cancer)Familial hemophagocytic lymphohistiocytosis 5Possible roles in metabolic diseases (via insulin signaling)Other (potentially immune diseases due to cytokine signaling)
04
Safety considerations
Potential challenges could include broad effects on multiple signaling pathways due to regulatory role across various cell types; concerns with immune modulation and effects on glucose metabolism are possible but specific safety data are not detailed in the sources
05
Biomarkers
Investigational biomarker for early detection of triple-negative breast cancer and other subtypes
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