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Target intelligence / Profile preview
Receptor Tyrosine Kinase–like Orphan Receptor 2 (ROR2)
- Target
- ROR2
- Molecular classification
- Receptor tyrosine kinase, Transmembrane receptor
01
Overview
ROR2 is a transmembrane receptor tyrosine kinase involved in the Wnt signaling pathway. It plays roles in cell proliferation, differentiation, migration, and apoptosis. Overexpression of ROR2 has been observed in several carcinomas and is independent of patient age, gender, tumor type or differentiation status.
- Other names
- NTRKR2
02
Mechanism of action
Antibody-drug conjugate targeting ROR2 delivers monomethyl auristatin E (MMAE) to inhibit tubulin polymerization, leading to mitotic arrest and apoptosis in ROR2-expressing cells.
03
Biological functions
Cell proliferationCell differentiationCell migrationApoptosisWnt signalingNon-canonical Wnt5A signaling
04
Disease associations
Cancer
05
Safety considerations
Off-target effects of MMAEImmunogenicity of the antibodyToxicities associated with tubulin polymerization inhibitors
06
Interacting drugs
Ozuriftamab vedotin (BA3021)
1 more in the full profile.
07
Biomarkers
ROR2 expression levels in tumor cells
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