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Target intelligence / Profile preview
Receptor tyrosine kinase-like orphan receptor 2 (ROR2)
- Target
- ROR2
- Molecular classification
- Receptor tyrosine kinase, Type I transmembrane protein
01
Overview
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor tyrosine kinase involved in noncanonical and canonical Wnt signaling pathways. It plays crucial roles in skeletal and neural development. ROR2 interacts with WNT5A and Frizzled receptors to transduce signals. Dysregulation of ROR2 is associated with developmental disorders like Robinow syndrome and Brachydactyly type B, as well as various cancers, including renal cell carcinoma.
- Other names
- Tyrosine-protein kinase receptor ROR2
02
Biological functions
Noncanonical Wnt signalingCanonical Wnt signaling modulationSkeletal developmentBone growthCartilage growthChondrocyte formationGrowth plate developmentNeurite outgrowthNeurite branchingTissue morphogenesis
03
Disease associations
Robinow syndromeBrachydactyly type BCancerRenal cell carcinomaMetastatic diseasesSkeletal dysplasia
04
Safety considerations
Aberrant activation linked to metastatic diseasesDysregulation associated with developmental disorders
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