Target intelligence / Profile preview

Receptor Tyrosine Kinases (RTKs)

Target: RTKs
Molecular classification: Receptor, Enzyme

Overview

Receptor tyrosine kinases (RTKs) are cell surface receptors that initiate signaling upon binding to extracellular ligands, leading to receptor activation and phosphorylation. This triggers downstream signaling cascades like the RAS/MAPK/ERK pathway, regulating cell growth, differentiation, and survival. They are frequently dysregulated in cancer and are important therapeutic targets.

Other names: Receptor Tyrosine Kinase

Mechanism of action

Inhibition of tyrosine kinase activity

Biological functions

Signal transductionCell proliferationCell differentiationCell survivalAngiogenesis

Disease associations

Cancer

Safety considerations

ResistanceOff-target effects

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