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Target intelligence / Profile preview
Receptor tyrosine-protein kinase erbB (ErbB)
- Target
- ErbB
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK)
01
Overview
Receptor tyrosine-protein kinase erbB refers to a family of membrane-bound receptor tyrosine kinases (RTKs) known as the ErbB or HER family. These receptors play critical roles in cell signaling, growth, differentiation, and survival. The family includes four main members: ErbB1 (EGFR/HER1), ErbB2 (HER2/neu), ErbB3 (HER3), and ErbB4 (HER4). Dysregulation of these receptors is implicated in various cancers.
- Other names
- HER familyEpidermal Growth Factor Receptor family
02
Mechanism of action
Ligand binding induces receptor dimerization and activation of tyrosine kinase activity, leading to autophosphorylation and downstream signaling cascade activation.
03
Biological functions
Cell signalingGrowthDifferentiationSurvivalCell proliferation
04
Disease associations
CancerBreast cancerLung cancerColorectal cancerOvarian cancer
05
Safety considerations
Embryonic lethality with null mutationsPotential for off-target effects with kinase inhibitorsDevelopment of resistance to targeted therapies
06
Interacting drugs
Monoclonal antibodies against EGFR
3 more in the full profile.
07
Biomarkers
EGFR expression levelsHER2 expression levelsHER2 amplification
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