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Target intelligence / Profile preview
Receptor tyrosine-protein kinase erbB-4 (ERBB4)
- Target
- ERBB4
- Molecular classification
- Receptor, Tyrosine Kinase, Transmembrane Receptor
01
Overview
Receptor tyrosine-protein kinase erbB-4 (ERBB4/HER4) is a transmembrane receptor tyrosine kinase that belongs to the epidermal growth factor receptor (EGFR/ErbB/HER) family. Upon ligand binding, it dimerizes and activates downstream signaling pathways like PI3K-AKT and Ras-MAPK, influencing various cellular processes. It plays crucial roles in heart development, the central nervous system, and mammary gland function. Aberrant ERBB4 signaling is implicated in cancer and neurological disorders.
- Other names
- HER4ErbB4
02
Mechanism of action
Tyrosine kinase inhibition (for potential therapeutics)
03
Biological functions
Cell survivalCell proliferationCell differentiationCell migrationAngiogenesisApoptosisGene transcriptionDevelopmentSignal transduction
04
Disease associations
CancerNeurological DisordersAmyotrophic Lateral SclerosisFrontotemporal DementiaSchizophrenia
05
Safety considerations
Aberrant signaling can lead to tumorigenesisPotential for off-target effects when targeting ErbB family members
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