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Target intelligence / Profile preview
Receptor tyrosine-protein kinase erbB4 (HER4)
- Target
- HER4
- Molecular classification
- Receptor, Receptor tyrosine kinase, ErbB/Epidermal Growth Factor Receptor family, Type I membrane glycoprotein
01
Overview
Receptor tyrosine-protein kinase erbB4 (HER4) is a member of the ErbB family of receptor tyrosine kinases. It plays critical roles in the development and maintenance of the cardiovascular system, central nervous system, and mammary gland. Ligand binding, such as Neuregulins, promotes dimerization and activation of downstream signaling pathways like MAPK/ERK. Mutations in ERBB4 have been identified in various cancers and neurodegenerative diseases. Multiple isoforms exist due to alternative splicing, leading to functional diversity.
- Other names
- ERBB4Herstatin receptor
02
Mechanism of action
Tyrosine kinase inhibition upon ligand binding and dimerization, leading to downstream signaling pathway modulation.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationApoptosisDevelopment and maintenance of cardiovascular systemCentral nervous system developmentMammary gland differentiationInduction of milk proteinsLactationRegulation of gene transcriptionAxon guidanceNeural crest cell migration
04
Disease associations
CancerMelanomaLung adenocarcinomaMedulloblastomaNeurodegenerative diseaseAmyotrophic Lateral Sclerosis
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