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Target intelligence / Profile preview
Receptor tyrosine-protein kinase RET (RET)
- Target
- RET
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
RET (Rearranged during Transfection) is a receptor tyrosine kinase that plays essential roles in cell signaling, particularly in the development and maintenance of neural crest-derived cells, the urogenital system, and both central and peripheral nervous systems. It is crucial for kidney development, enteric neuron formation, and spermatogenesis. Mutations in RET are associated with various diseases, including Hirschsprung's disease and several types of cancer. Activation occurs through ligand binding to GFRα co-receptors, leading to RET dimerization and autophosphorylation.
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell survivalCell proliferationCell differentiationNeuronal developmentKidney morphogenesisSpermatogenesis
04
Disease associations
CancerHirschsprung's diseaseMultiple endocrine neoplasia type 2A/2BPapillary thyroid carcinomaPheochromocytomaParathyroid hyperplasia
05
Safety considerations
Off-target effects of RET inhibitorsDevelopmental toxicity
06
Biomarkers
RET mutations (e.g., in thyroid cancer)RET fusions
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