Recipient immune cells via cell surface receptors

Recipient immune cells via cell surface receptors is a descriptive term rather than a specific molecular target, referring to the diverse set of proteins expressed on the plasma membranes of a host's immune cells that mediate communication and activation (Abbas et al., 2014). These receptors include T-cell receptors (TCRs), B-cell receptors (BCRs), and Toll-like receptors (TLRs), which are fundamental for identifying pathogens and foreign tissues (Janeway et al., 2001). In therapeutic contexts, these receptors serve as the primary interface for drugs designed to modulate the immune system, such as checkpoint inhibitors or immunosuppressants (Waldmann, 2003). For instance, chimeric antigen receptor (CAR) T-cell therapies must interact with or navigate the recipient's immune environment to ensure persistence and avoid rejection (June et al., 2018). Because this term encompasses hundreds of different molecular targets across multiple cell types, it does not represent a single, discrete therapeutic target in pharmacological nomenclature. Instead, it serves as a conceptual framework for understanding the pharmacodynamics of immunomodulatory agents and the potential for adverse events like cytokine release syndrome (Shimabukuro-Vornhagen et al., 2018).

Other names

Host immune cell surface receptorsRecipient leukocyte receptorsImmune cell membrane proteins

Engagement of various surface receptors on host immune cells to modulate systemic or local immune activity.