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Target intelligence / Profile preview
Recombinant Factor VIIa (rFVIIa)
- Target
- rFVIIa
- Molecular classification
- Recombinant protein, Serine protease, Coagulation factor
01
Overview
Recombinant Factor VIIa (rFVIIa) is a genetically engineered form of activated human coagulation factor VII. It promotes hemostasis by activating factor X, leading to thrombin and fibrin generation, bypassing deficiencies or inhibitors against factors VIII or IX. It is used primarily in hemophilia patients with inhibitors, congenital factor VII deficiency, and, in some cases, Glanzmann's thrombasthenia. Off-label uses include severe bleeding situations like trauma or postpartum hemorrhage.
- Other names
- Activated recombinant coagulation factor VIINovoSevenNiastase RTSevenfact
02
Mechanism of action
Activates FX via TF-dependent/independent pathways; boosts local thrombin/fibrin production
03
Biological functions
HemostasisBlood coagulationThrombin generationFibrin formation
04
Disease associations
Hemophilia A with inhibitorsHemophilia B with inhibitorsCongenital factor VII deficiencyGlanzmann's thrombastheniaTraumatic hemorrhage (off-label)Postpartum hemorrhage (off-label)
05
Safety considerations
Thromboembolic eventsAntibody formationHigh costLack of predictive laboratory tests for efficacy
06
Interacting drugs
NovoSeven
2 more in the full profile.
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