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Target intelligence / Profile preview
Recombinase A Homolog 1 (RAD51)
- Target
- RAD51
- Molecular classification
- Enzyme, Recombinase, ATPase
01
Overview
RAD51 recombinase is a highly conserved protein in eukaryotes that plays a central role in homologous recombination (HR), a critical pathway for the repair of DNA double-strand breaks (DSBs). It is essential for maintaining genomic stability, preventing mutations, and supporting accurate DNA replication and cell division. Misregulation or mutation in RAD51 can lead to genomic instability associated with cancer predisposition syndromes. Overexpression has been linked with resistance mechanisms against chemotherapy-induced apoptosis in certain cancers—making it both a biomarker and potential therapeutic target.
- Other names
- RAD51 Recombinase
02
Mechanism of action
Pharmacological inhibition of RAD51 activity is under investigation.
03
Biological functions
Homologous recombinationDNA repairMaintenance of genomic stabilityMeiosisDNA replication
04
Disease associations
CancerFanconi anemiaHereditary breast/ovarian cancerChemoresistance
05
Safety considerations
Inhibition of RAD51 may disrupt DNA repair processes in normal cells.Potential for off-target effects due to high conservation of RAD51 across species.Altered meiosis
06
Biomarkers
RAD51 overexpression (in some cancers)
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