RecQ-mediated genome instability protein 2 (RMI2)

RecQ-mediated genome instability protein 2 (RMI2) is a small, evolutionarily conserved accessory protein within the BLM complex (consisting of BLM helicase, Topoisomerase IIIα, RMI1, and RMI2). RMI2 contains a single OB-fold, enabling protein-protein interactions rather than direct nucleic acid binding. Its critical function is to stabilize the BLM complex by interacting with RMI1 via hydrophobic and electrostatic contacts, enabling the dissolution of double Holliday junction intermediates—key DNA repair events that suppress crossovers and maintain chromosomal stability. It is required for proper mitotic and meiotic recombination, suppresses inappropriate sister chromatid exchange, and is essential for preventing genome instability. Loss or mutation of RMI2 (or BLM complex disruption) is linked to increased genome instability and the cancer-prone disorder Bloom syndrome[1][2][3][5].

Other names

BLM-associated protein of 18 kDaC16orf75hRMI2BLAP18MGC24665RecQ mediated genome instability 2, homologRMI2_HUMANQ96E14