Rectal mucosa

The **rectal mucosa** is the innermost lining layer of the rectum. It consists primarily of simple columnar epithelial cells interspersed with mucus-secreting goblet cells, supported by connective tissue known as lamina propria and a thin muscle layer called muscularis mucosae[6][7][8]. The main functions include absorbing water and electrolytes from feces to help solidify stool before defecation, secreting mucus to lubricate stool passage, and serving as a barrier against pathogens and mechanical injury[1][3][6]. The structure transitions sharply at the anorectal junction where it meets stratified squamous epithelium. While diseases such as cancer can arise from this tissue—most commonly adenocarcinoma—the "rectal mucosa" itself is an anatomical structure rather than a discrete therapeutic target like an enzyme or receptor. Therefore, it should not be classified as a druggable molecular target. **Note:** There is something incorrect about using "Rectal mucosa" as a therapeutic target name—it refers to an anatomical tissue layer rather than any single molecule/receptor/enzyme/transporter typically considered drug targets. If you are seeking information about receptors or molecules expressed within this tissue (such as certain ion channels or transporters), those should be specified individually.

Other names

Rectal liningMucosa of the rectumRectal epithelial layer

Drugs do not act on the "rectal mucosa" as a molecular entity but may be absorbed through it or cause local effects.