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Red Blood Cell Aggregation (RBC Aggregation)

Target: RBC Aggregation
Molecular classification: Biophysical Phenomenon

Overview

Red blood cell aggregation refers to the reversible clumping or stacking of red blood cells (RBCs) under conditions of low shear force or stasis. This phenomenon is a normal physiological process but can be altered in various disease states. It is primarily mediated by fibrinogen and other high-molecular-weight plasma proteins and affects blood viscosity at low shear rates, making it a key determinant in microcirculatory flow dynamics.

Other names: Erythrocyte AggregationRouleaux Formation

Biological functions

Blood viscosity regulationMicrocirculatory flow dynamics

Disease associations

InfectionsInflammatory statesCirculatory disordersMetabolic disordersHematological diseasesDiabetes mellitus

Safety considerations

Increased blood viscosityMicrocirculatory disturbances

Biomarkers

Aggregate size distributionAggregation index

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