Redox-active and inflammatory enzymes

Redox-active and inflammatory enzymes represent a broad class of proteins that facilitate electron transfer and the production of reactive molecular species during immune activation. This group includes key therapeutic targets such as cyclooxygenases (COX-1, COX-2), lipoxygenases (5-LOX), NADPH oxidases (NOX), and inducible nitric oxide synthase (iNOS) (Source: PubMed, PMID: 28652145). These enzymes are responsible for synthesizing potent inflammatory mediators like prostaglandins and leukotrienes, as well as reactive oxygen and nitrogen species (ROS/RNS) that contribute to oxidative stress (Source: NIH, StatPearls). While essential for host defense and cellular signaling, their chronic overactivation is linked to the pathogenesis of atherosclerosis, rheumatoid arthritis, Alzheimer's disease, and various cancers (Source: UniProt). Drugs targeting these enzymes, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and specific NOX or MPO inhibitors, work by blocking the catalytic sites to reduce the inflammatory burden and oxidative damage (Source: PubChem). Monitoring the activity of these enzymes through biomarkers like myeloperoxidase (MPO) levels or lipid peroxidation products is crucial for assessing disease severity and treatment efficacy.

Other names

Inflammatory oxidoreductasesPro-inflammatory redox enzymesOxidative stress-related enzymes

Inhibition of enzymatic activity to decrease the synthesis of pro-inflammatory mediators and reactive oxygen or nitrogen species.