Redox-active enzyme and cellular antioxidant system

Redox-active enzymes and cellular antioxidant systems" is not a single molecular target but a broad functional category that includes a range of enzymes and pathways responsible for neutralizing reactive oxygen species (ROS) and maintaining redox balance within cells. Major enzyme families include superoxide dismutases (SODs), catalase, glutathione peroxidases (GPx), thioredoxins, glutaredoxins, and peroxiredoxins, alongside non-enzymatic antioxidants like glutathione and vitamins C and E. These molecules act cooperatively to prevent oxidative damage to cellular macromolecules and modulate cell signaling. Dysfunction in these systems is implicated in numerous diseases such as cancer, neurodegeneration, cardiovascular and inflammatory disorders. Therapeutic agents can target these enzymes or systems to enhance antioxidant capacity or selectively modulate redox signaling[1][2][3][4][5][6][7]. **Note:** This entry is **not a specific target** but a functional group; it aggregates several molecular classes and mechanisms and should be split into specific enzymes (e.g., "Superoxide dismutase 1," "Catalase," "Glutathione peroxidase 1") for structured target-based applications.

Other names

Redox-active enzymesAntioxidant enzymesCellular antioxidant systemsROS detoxifying systems

Scavenging reactive oxygen species Enhancing expression or activity of endogenous antioxidant enzymes (e.g., SOD mimetics) Direct reduction or neutralization of oxidants Modulation of redox-sensitive signaling pathways (e.g., NRF2 activation)