Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Reduced Expression in Immortalized Cells Protein (REIC)
- Target
- REIC
- Molecular classification
- Wnt signaling inhibitor, Secreted protein
01
Overview
REIC (Reduced Expression in Immortalized Cells) is a protein encoded by the Dkk-3 gene. It functions as a tumor suppressor and inhibitor of the Wnt signaling pathway. Its expression is significantly reduced or absent in many cancer types, making it a potential therapeutic target for restoring Wnt pathway regulation and suppressing tumor growth.
- Other names
- Dkk-3Dickkopf-related protein 3
02
Mechanism of action
Wnt pathway inhibition (potential therapeutic strategy)
03
Biological functions
Tumor suppressionNegative regulation of Wnt signalingCell growth regulationCell differentiation regulation
04
Disease associations
Cancer
05
Safety considerations
Potential off-target effects when manipulating Wnt signaling
06
Biomarkers
Down-regulation in various cancers (potential diagnostic biomarker)REIC/Dkk-3 expression levels in tumor tissue
Beyond the preview
Go deeper on Reduced Expression in Immortalized Cells Protein (REIC).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Reduced Expression in Immortalized Cells Protein (REIC).