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Reduced Folate Carrier
- Molecular classification
- Transporter, Major Facilitator Superfamily (MFS)
01
Overview
The reduced folate carrier (RFC), encoded by the SLC19A1 gene, is a ubiquitously expressed membrane transporter and the principal system for importing reduced folates into mammalian cells. Folates are essential nutrients required for one-carbon transfer reactions, which are critical in nucleic acid synthesis and amino acid metabolism during cell division. Mammals cannot synthesize folates de novo and thus depend on RFC-mediated uptake from extracellular sources.
02
Mechanism of action
Inhibition of folate uptake, decreased intracellular drug accumulation
03
Biological functions
Folate transportNutrient uptakeDrug transportAnion exchange
04
Disease associations
Developmental defectsNeurological disordersCardiovascular diseaseFetal abnormalitiesCancerChemotherapy resistance
05
Safety considerations
Chemotherapy resistanceImpaired folate uptake leading to metabolic disorders
06
Interacting drugs
Methotrexate
1 more in the full profile.
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