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Target intelligence / Profile preview
Reduced Folate Carrier Protein 1 (RFC-1)
- Target
- RFC-1
- Molecular classification
- Transmembrane transporter, Solute carrier
01
Overview
Reduced Folate Carrier Protein 1 (RFC-1), encoded by the SLC19A1 gene, is the primary transporter responsible for the uptake of reduced folates into mammalian cells. It is essential for maintaining intracellular folate concentrations necessary for DNA synthesis, repair, and methylation. RFC-1 also mediates the uptake of antifolate drugs like methotrexate, and genetic polymorphisms can affect drug efficacy and toxicity. Recent studies indicate a role in importing immune second messengers such as cGAMP.
- Other names
- Folate transporter 1Intestinal folate carrier 1hRFCRFT-1solute carrier family 19 member 1
02
Mechanism of action
Carrier-mediated transport of folates and antifolates across cell membranes; import of immunotransmitters like cGAMP.
03
Biological functions
Folate transportDrug transportImmune signaling molecule transportMaintenance of intracellular folate concentrationsDNA synthesisDNA repairMethylation reactions
04
Disease associations
Neural tube defectsMegaloblastic anemiaDevelopmental disordersRetinal vascular diseasesCancer
05
Safety considerations
Methotrexate toxicityIndividual variability in drug response due to genetic polymorphisms
06
Interacting drugs
Methotrexate
07
Biomarkers
SLC19A1 genetic polymorphisms (e.g., c.80GG, c.80AA)
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