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Reduced Folate Transporter (RFC)
- Target
- RFC
- Molecular classification
- Membrane-bound solute carrier, Antiporter, Major Facilitator Superfamily (MFS) transporter
01
Overview
The reduced folate transporter (RFC), also known as SLC19A1, is a ubiquitously expressed membrane protein that serves as the primary transporter for reduced folates in mammalian cells and tissues. It functions as an antiporter, mediating the import of reduced folates and cyclic dinucleotides in exchange for organic anions. RFC plays a crucial role in cellular folate uptake, essential for one-carbon metabolism. It is also a key mediator of antifolate drug uptake, making it clinically relevant in cancer chemotherapy and drug resistance.
- Other names
- SLC19A1FLOT1Cyclic dinucleotide:anion antiporter SLC19A1Folate:anion antiporter SLC19A1
02
Mechanism of action
RFC mediates the cellular uptake of antifolate drugs like methotrexate.
03
Biological functions
Import of reduced folatesImport of cyclic dinucleotidesExport of organic anionsNutrient transport
04
Disease associations
CancerCardiovascular disordersFetal abnormalitiesNeurological conditionsAntifolate drug resistanceHereditary disorders
05
Safety considerations
Antifolate drug resistance developmentImpaired folate uptake leading to physiological abnormalities
06
Interacting drugs
Methotrexate
07
Biomarkers
RFC expression levels (predictive of antifolate drug response)
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