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Reelin (None)

Target: None
Molecular classification: Secreted extracellular glycoprotein

Overview

Reelin is a large, secreted extracellular glycoprotein that plays a critical role in brain development and function. It regulates neuronal migration, dendritic growth, synaptogenesis, and synaptic plasticity. Reelin signaling is essential for proper cortical layer formation, and disruptions are linked to several neurodevelopmental and neuropsychiatric disorders.

Other names: RELN

Mechanism of action

Reelin binds to ApoER2 and VLDLR, triggering phosphorylation of Dab1 and activating Src family kinases, ultimately regulating cytoskeletal dynamics.

Biological functions

Regulation of radial glia scaffold formationControl over neuronal positioning/layering during corticogenesisPromotion of dendritic arborization/spine formationModulation of synapse formation/plasticity

Disease associations

LissencephalyAutism spectrum disordersSchizophreniaBipolar disorderDepressionAlzheimer’s diseaseEpilepsy

Safety considerations

Disruptions in Reelin signaling are linked to several neurodevelopmental and neuropsychiatric disorders, suggesting that interventions must be carefully targeted to avoid unintended consequences.

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