Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Regulated in Development and DNA Damage Response 1 (REDD1)
- Target
- REDD1
- Molecular classification
- Stress response protein
01
Overview
REDD1, also known as DDIT4, is a 25 kDa stress response protein that plays crucial roles in cellular stress adaptation, metabolic regulation, and redox homeostasis. It acts as a negative regulator of mTORC1 and is implicated in various diseases including diabetes, cancer, and neurodegenerative disorders. It has potential as a therapeutic target for conditions characterized by persistent cellular stress and metabolic dysregulation.
- Other names
- DDIT4DNA-damage-inducible transcript 4RTP801
02
Mechanism of action
mTORC1 inhibition via TSC1/TSC2 stabilization, ROS modulation, GR modulator
03
Biological functions
Stress response regulationmTORC1 pathway inhibitionRedox regulationNegative regulation of cell growthNegative regulation of protein synthesisRedox sensor
04
Disease associations
DiabetesDiabetic complicationsCancerSkin atrophyNeurodegenerative disorders
05
Safety considerations
Chronic elevation contributes to disease progressionDual role in redox homeostasis (can promote oxidative stress)
06
Interacting drugs
Metformin
Beyond the preview
Go deeper on Regulated in Development and DNA Damage Response 1 (REDD1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Regulated in Development and DNA Damage Response 1 (REDD1).