Regulating synaptic membrane exocytosis protein 1 (RIMS1)

Regulating synaptic membrane exocytosis protein 1 (RIMS1) is a multidomain scaffold protein critical for neurotransmitter release at the presynaptic active zone in neurons. As part of the cytomatrix, RIMS1 coordinates docking, priming, and exocytosis of synaptic vesicles by interacting with components including Rab3A, Munc13, voltage-gated calcium channels, and multiple active zone proteins. RIMS1 thus regulates both the probability and timing of neurotransmitter release and is essential for normal synaptic transmission and presynaptic plasticity. Mutations in RIMS1 are causative of cone-rod dystrophy 7, an inherited retinal degenerative disorder. RIMS1 also functions in nonneuronal secretory systems, such as insulin release from pancreatic β-cells and acrosomal exocytosis in sperm.

Other names

KIAA0340RAB3IP2RIM1Nbla00761RIM 1RIMRab-3-interacting molecule 1Rab-3-interacting protein 2Rab3-interacting moleculeCORD7RIMS1

Drugs or experimental molecules targeting RIMS1 would generally aim to modulate synaptic vesicle release, neurotransmission, or presynaptic calcium channel tethering. Mechanisms could involve inhibition or enhancement of protein-protein interactions in the active zone, or modulation of calcium channel localization.