Regulating synaptic membrane exocytosis protein 2 (RIMS2)

Regulating synaptic membrane exocytosis protein 2 (RIMS2) is a presynaptic scaffold protein essential for efficient neurotransmitter release in the central nervous system[1][2][3][4]. It interacts with RAB3, Munc13, and other synaptic proteins at the active zone, orchestrating membrane docking and calcium-triggered exocytosis of synaptic vesicles[1][2]. RIMS2 plays vital roles beyond the brain, including in sensory neurons and metabolic tissues such as the pancreas, where it affects insulin secretion[2]. Loss-of-function mutations in RIMS2 cause congenital cone-rod synaptic disorder, sometimes associated with neurodevelopmental and metabolic deficits[2]. Variant expression is associated with certain neuropsychiatric and metabolic conditions. RIMS2 is not a traditional drug target (e.g., receptor or enzyme), and no drugs are currently known to interact directly with it, though its function is fundamental to neurotransmitter release processes[1][2][3][4].

Other names

RAB3IP3RIM2OBOEKIAA0751Rab-3-interacting molecule 2Rab-3-interacting protein 3CRSDS