Regulating synaptic membrane exocytosis protein 3 (RIMS3)

Regulating synaptic membrane exocytosis protein 3 (RIMS3) is a scaffolding protein localized to the presynaptic active zone of neurons, where it plays a crucial role in organizing the presynaptic machinery and regulating neurotransmitter release by facilitating synaptic vesicle exocytosis. RIMS3 is predicted to bind transmembrane transporters and is involved in calcium ion-regulated exocytosis of neurotransmitters. Genetic variations affecting RIMS3, such as deletions, have been implicated in neurodevelopmental disorders including autism and may be associated with other nervous system diseases such as schizophrenia, indicating its importance for correct synaptic function[1][3][4][5][6].

Other names

RIMS3NIM3RIM3RIM 3RIM3 gammaRab-3-interacting molecule 3KIAA0237