Regulating synaptic membrane exocytosis protein 4 (RIMS4)

Regulating synaptic membrane exocytosis protein 4 (RIMS4) is a scaffold protein that localizes to the presynaptic active zone of neurons, where it organizes the molecular machinery that enables synaptic vesicle docking, priming, and fusion. RIMS4 interacts with other active zone components, including Rab3-interacting proteins, and is predicted to play a key role in neurotransmitter release at glutamatergic synapses by controlling the exocytosis of synaptic vesicles. It is implicated in regulating synaptic membrane potential, synapse organization, and transporter binding, and its dysfunction is associated with several neurodevelopmental and neuropsychiatric disorders. The gene is most commonly abbreviated as RIMS4, while its canonical full name is "Regulating synaptic membrane exocytosis protein 4". RIMS4 belongs to a protein family that includes important regulators of synaptic function, but specific drug interactions or therapeutic agents targeting this protein are not described in available sources.

Other names

C20orf190RIM 4dJ781B1.3RIM4 gammaRab3-interacting molecule 4RIM4-gammaregulating synaptic membrane exocytosis protein 4rab3-interacting molecule 4RIMS4