Regulation of Smad signaling pathway

The Smad pathway is a central signaling mechanism that transduces extracellular signals from the TGF-β superfamily of cytokines (including TGF-βs, activins, and BMPs) through membrane serine/threonine kinase receptors to intracellular Smad proteins, which then regulate gene transcription in the nucleus. Regulation of the Smad pathway refers to the finely-tuned modulation of Smad protein activation, nuclear translocation, complex formation, and DNA binding, as well as modulation by inhibitory factors (e.g., Smad7). Smad pathway regulation ensures context-dependent outcomes such as growth arrest, differentiation, immune modulation, and tissue remodeling, and its dysregulation is implicated in cancer, fibrosis, inflammatory and autoimmune diseases. Note: If your intention is to find a single molecule, such as a Smad protein (e.g., Smad2, Smad3, Smad4, Smad7) or a receptor (e.g., TGF-β receptor I/II), you should specify that molecule or gene, as "Smad pathway regulation" is not itself a single canonical target.

Other names

Smad signaling regulationRegulation of Smad pathwaySmad-dependent signaling regulation