Regulator of G protein signaling 10 (RGS10)

Regulator of G protein signaling 10 (RGS10) is a member of the RGS protein family, which functions as a GTPase-activating protein (GAP) specific for Gα subunits of heterotrimeric G proteins, particularly in the Gi/o/z class[1][3][5]. RGS10 accelerates the conversion of active GTP-bound Gα subunits to their inactive GDP-bound form, thereby terminating GPCR signaling. It is a small cytosolic protein highly expressed in the brain, immune cells, platelets, and cells involved in bone remodeling. Distinct isoforms (RGS10A and RGS10B) exist due to alternative splicing. RGS10 regulates critical biological processes including signal transduction, immune response, osteoclast and chondrocyte differentiation, platelet activation, and cardiac remodeling. Dysregulation of RGS10 has been implicated in a range of pathologies, such as neurodegenerative diseases, cancer, cardiovascular disease, osteopetrosis, thrombosis, and inflammatory disorders. Currently, there are no approved drugs targeting RGS10, but its pivotal regulatory roles make it a promising therapeutic target for multiple conditions[2][3][4][5].

Other names

RGS10Regulator of G-protein signaling 10Regulator of G protein signalling 10RGS10A (isoform)RGS10B (isoform)

GTPase-activating protein; acts by accelerating GTP hydrolysis on Gα subunits to terminate signaling downstream of G protein-coupled receptors (GPCRs)[1][5]. Negative regulation of Gi/o/z signaling pathways[1][5].