Regulator of G-protein signaling 7 (RGS7)

Regulator of G-protein signaling 7 (RGS7) is a member of the R7 subfamily of RGS proteins, highly expressed in the nervous system and periphery[2][3]. RGS7 functions as a GTPase-activating protein (GAP), accelerating the deactivation of heterotrimeric G proteins and hence attenuating GPCR signaling. It forms multisubunit complexes (particularly with Gβ5 and R7BP) required for precise spatial and temporal control of GPCR pathways involved in neurotransmission, vision, learning, memory, and metabolic regulation[1][2]. RGS7 interacts with several family members, unique orphan GPCRs (GPR158, GPR179), and anchoring proteins (R7BP, R9AP), affecting its cellular localization and activity[1][2]. Disruption of RGS7 function is linked to neuropsychiatric diseases, cancer, and diabetes, and the RGS7 complex is under investigation as a drug target to improve the efficacy and safety of GPCR-modulating therapies[1].

Other names

RGS7Regulator of G protein signaling 7regulator of G-protein signaling RGS7regulator of G-protein signalling 7Regulator of G-protein signaling 7, RGS7regulator of G protein signaling 7

Drugs targeting RGS7 would act by inhibiting or enhancing its GAP activity, thus prolonging or reducing GPCR signaling. Potential mechanisms include allosteric modulation of RGS7-Gβ5 complex formation and stabilization or disruption of RGS7 interactions with protein partners (such as R7BP, GPR158, GPR179).