Regulator of G protein signaling like 1 (RGSL1)

Regulator of G protein signaling like 1 (RGSL1) is a protein-coding gene belonging to the regulator of G protein signaling (RGS) family, which typically act by accelerating the GTPase activity of Gα subunits to attenuate G protein-coupled receptor signaling. RGSL1 has been genetically associated with familial hypertrophic cardiomyopathy type 2, leukoencephalopathy with vanishing white matter, and has been found to harbor missense mutations in some cases of breast cancer. Unlike canonical therapeutic targets, RGSL1 does not correspond to a recognized druggable receptor, enzyme, transporter, or ion channel, and there is limited evidence of direct pharmacological targeting or established pathogenic mechanism. It is sometimes confused with RGSL2 due to alias overlap. There are no known interacting drugs or well-described mechanisms of action targeting this gene, and its classification as a therapeutic target is unclear based on current data[1][2][7].

Other names

Regulator of G-protein signaling protein-likeRGSL1RGSLRGSL2Regulator of G-protein signaling like 2Regulator of G-protein signalling like 1Regulator of G-protein signalling like 2