Regulator of microtubule dynamics protein 2 (RMDN2)

RMDN2 (Regulator of microtubule dynamics protein 2) is a protein encoded by the human RMDN2 gene and is characterized by multiple coiled-coil domains that enable microtubule binding and regulation of microtubule dynamics during cell division[1][3][4][6][8][9]. The protein is found in the cytosol during interphase and relocalizes to spindle microtubules and spindle poles during mitosis[9]. It is also detected in the Golgi apparatus and other cytoplasmic locations[6][8]. RMDN2 is broadly expressed in human tissues, with notable expression in multiple brain regions, including the temporal lobe[7][2]. Though not considered an established drug target, recent genome-wide association studies have linked genetic variation near RMDN2 to increased tau deposition in Alzheimer’s disease, and its expression is downregulated in Alzheimer’s brain tissue, suggesting a potential, yet not fully defined, role in neurodegenerative disease etiology[2]. There are currently no known drugs that directly target this protein, nor defined mechanisms of action or specific safety concerns reported.

Other names

FAM82AFAM82A1BLOCK18UNQ9371/PRO34163RMD-2hRMD-2FLJ32954RMD2Protein FAM82A1PRO34163PYST9371RMD4family with sequence similarity 82 member Afamily with sequence similarity 82 member A1microtubule-associated protein