Regulator of thyroid function and cancer (RTFC)

Regulator of thyroid function and cancer (RTFC), encoded by the C14orf93 gene, is a recently characterized human protein implicated in thyroid biology and cancer. RTFC was identified as a susceptibility gene for familial non-medullary thyroid cancer (FNMTC), with several missense mutations (e.g., R115Q, V205M, G209D) shown to enhance thyroid cancer cell survival, migration, and the ability to transform normal thyroid cells[6][2][4][1]. In vitro knockout studies in mouse embryonic stem cells demonstrate that RTFC promotes thyroid lineage differentiation, and loss of function impairs this process[1][2][4]. RTFC is predicted to enable RNA binding activity and may act as a transcriptional regulator involved in positive regulation of gene expression and cell differentiation[2][3][5]. RTFC is also recognized as a potential antigen in certain peripheral T-cell lymphomas[2]. However, no clinically approved drugs are known to target RTFC, and its detailed molecular mechanism and broader physiological roles remain under investigation.

Other names

C14orf93Chromosome 14 open reading frame 93FLJ12154Regulator of thyroid function and cancerRTFC4931414P19Rik (mouse homolog)RIKEN cDNA 4931414P19 geneSimilar to human chromosome 14 open reading frame 93Uncharacterized protein C14orf93