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Target intelligence / Profile preview
Regulatory Macrophage (Mreg)
- Target
- Mreg
- Molecular classification
- Immune cell, Myeloid cell, Macrophage subset
01
Overview
Regulatory macrophages (Mregs) are a subset of macrophages with potent immunoregulatory properties. They are characterized by high IL-10 production, variable TGF-β production, and low IL-12 production. Mregs are induced by dual stimulation with a TLR ligand (e.g., LPS) and a secondary signal (e.g., PGE₂). They suppress inflammation, promote tolerance, and can be used therapeutically for autoimmune diseases and transplant rejection, but their immunosuppressive nature presents infection risks.
- Other names
- RMϕM2b MacrophageImmunoregulatory Macrophage
02
Mechanism of action
Macrophage polarization towards an anti-inflammatory and tolerogenic phenotype, suppressing pro-inflammatory cytokine production (IL-1β, IL-6, TNFα) and promoting Treg expansion via TGF-β secretion.
03
Biological functions
Immune suppressionTolerance inductionTreg inductionResolution of inflammationTissue repair (context-dependent)Antimicrobial activity (context-dependent)
04
Disease associations
Autoimmune diseasesTransplant rejectionChronic inflammatory conditionsInfection susceptibility (potential)Cancer (context-dependent)
05
Safety considerations
Increased susceptibility to infections due to immunosuppressionPotential for tumor promotion in certain contextsOff-target effects of induction stimuli
06
Interacting drugs
LPS (Lipopolysaccharide)
4 more in the full profile.
07
Biomarkers
IL-10 (high secretion)TGF-β (variable secretion)IL-12 (low/no secretion)Surface markers (protocol-dependent)
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