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Regulatory T cell (Treg) depletion via Fc gamma receptor-mediated cytotoxicity (None)
- Target
- None
- Molecular classification
- Other
01
Overview
Regulatory T cell (Treg) depletion via Fc gamma receptor (FcγR)-mediated cytotoxicity involves monoclonal antibodies that bind to surface molecules highly expressed on Tregs, such as CTLA-4 or CD25. These antibodies are engineered with Fc regions optimized for binding to activating FcγRs on effector immune cells like macrophages and natural killer (NK) cells. This engagement triggers antibody-dependent cellular cytotoxicity (ADCC) or antibody-dependent cellular phagocytosis (ADCP), leading to selective elimination of the targeted Treg population within tissues, especially tumors, enhancing anti-tumor immunity.
02
Mechanism of action
Monoclonal antibody binds surface antigen on Tregs -> Engagement of Fc gamma receptor on effector cells -> Triggers ADCC/ADCP -> Treg depletion
03
Biological functions
Immune responseSuppression of immune responseCell death
04
Disease associations
CancerAutoimmune disease
05
Safety considerations
Off-target effects on other immune cellsCytokine release syndromeExacerbation of autoimmune diseases
06
Interacting drugs
Anti-CTLA-4 mAbs
1 more in the full profile.
07
Biomarkers
Intratumoral Treg levelsExpression levels of target antigens (CTLA-4, CD25) on TregsFcgamma receptor polymorphisms
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