Regulatory T-cell expansion

Regulatory T-cell expansion refers to the increase in number and/or suppressive function of regulatory T cells (Tregs), a subset of T cells crucial for maintaining immune homeostasis and preventing autoimmunity. This process involves complex molecular pathways and cytokine signaling (e.g., IL-2, TGF-β). Therapeutic manipulation of Treg expansion holds promise for treating autoimmune diseases and promoting transplant tolerance, but requires careful consideration of potential safety concerns related to over-suppression of the immune system.

Other names

Treg expansionRegulatory T cell proliferationTreg amplificationFOXP3+ T cell expansion

Varies depending on the specific intervention used to promote Treg expansion. Examples include: IL-2 stimulation leading to STAT5 activation; TGF-β signaling promoting FOXP3 expression; modulation of metabolic pathways to favor Treg survival and function.