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Target intelligence / Profile preview
Relaxin Family Peptide Receptor 2 (RXFP2)
- Target
- RXFP2
- Molecular classification
- G protein-coupled receptor, GPCR, Leucine-rich repeat-containing GPCR, Receptor
01
Overview
Relaxin Family Peptide Receptor 2 (RXFP2) is a G protein-coupled receptor primarily activated by insulin-like peptide 3 (INSL3). It plays a crucial role in male reproductive development, specifically testicular descent. RXFP2 couples mainly to G_s proteins, leading to increased cAMP production, though it can also couple to some members of the G_i/G_o family. Mutations in RXFP2 are linked to cryptorchidism. While primarily known for its role in reproduction, RXFP2 is also implicated in connective tissue formation, bone metabolism, and potentially cardiovascular function and tissue remodeling.
- Other names
- Relaxin/insulin-like family peptide receptor 2
02
Mechanism of action
Agonist binding leading to G protein activation and downstream signaling (cAMP production)
03
Biological functions
Protein-hormone receptor activityG protein-coupled signal transductionSignal transductionConnective tissue formationBone metabolismCardiovascular functionTissue remodelingAnti-fibrotic processesAngiogenesisAnti-apoptotic effectsInflammation control
04
Disease associations
CryptorchidismMale infertilityFibrosis (potential)
05
Safety considerations
Potential for off-target effects due to shared properties with other relaxin family receptors.
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