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Release of Growth Factors and Cytokines

Molecular classification: Growth Factors, Cytokines, Signaling Molecules

Overview

The "release of growth factors and cytokines" refers to the biological process by which cells secrete these signaling molecules into their environment. Both growth factors and cytokines are proteins (or, less commonly, peptides or steroid hormones) that act as extracellular messengers, binding to specific receptors on target cells to regulate a wide range of cellular activities including proliferation, differentiation, migration, survival/death, immune responses, tissue repair, and homeostasis.

Mechanism of action

Inhibition of ligand production/release; Blocking receptor activity; Therapeutic administration of recombinant proteins

Biological functions

Cell proliferationCell differentiationCell migrationCell survivalImmune system activationImmune system inhibitionTissue developmentTissue repairWound healingAngiogenesisHomeostasis

Disease associations

CancerAutoimmune disordersChronic inflammationViral infections

Safety considerations

Off-target effectsCytokine stormImmunogenicity of recombinant proteins

Interacting drugs

EGF inhibitors

6 more in the full profile.

Biomarkers

Growth factor levelsCytokine levels

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