RELT-like protein 1 (RELL1)

RELT-like protein 1 (RELL1) is a type I transmembrane protein of the RELT family, containing a short extracellular domain and a variable intracellular domain likely important for protein stability and signaling[1][2][4][7]. Although termed a receptor, it lacks the conserved death domain typical of apoptosis-inducing TNFR family members and has not been shown to bind classical TNFSF ligands. RELL1 is expressed nearly ubiquitously, with particular abundance in bone marrow, placenta, and immune tissues[1][4]. It is regulated by interferons and exhibits circadian expression patterns in specific tissues. Functionally, RELL1 participates in activation of the p38 and JNK MAPK signaling cascades, induces apoptosis when overexpressed, inhibits cellular autophagy via mTOR interaction, and has emerging roles in immune modulation, tumor progression, and infection response[1][2][4][7]. While it is not yet a direct therapeutic target, its biology suggests possible relevance for future intervention in cancer, infection, and immune disorders[1][6].

Other names

RELL1RELT-like protein 1PSEC0162receptor expressed in lymphoid tissues like 1tmp_locus_29

Activation/inhibition of the MAPK14/p38 and JNK signaling pathways Inhibition of autophagy via activation of mTOR