Remodeling and spacing factor 1 (RSF1)

Remodeling and spacing factor 1 (RSF1) is a key chromatin remodeling factor that functions primarily as part of the RSF complex, in association with the SNF2H ATPase, to regulate nucleosome spacing and chromatin structure[2][3]. RSF1 is involved in transcriptional repression, acting as a reader for histone H2A ubiquitination (H2Aub), and directly participates in polycomb-mediated gene silencing and chromatin compaction[3]. It plays crucial roles in the DNA damage response, facilitating both homologous recombination and non-homologous end joining by recruiting repair factors such as XRCC4 and interacting with mitotic kinases and histone modifiers like HDAC1[1][4][6]. RSF1 controls centromere function, ensuring proper chromosome alignment and segregation during mitosis[6]. Overexpression of RSF1 is observed in multiple tumor types, implicating it in cancer progression and chemoresistance, while also modulating cell cycle regulators and inflammatory responses through interactions with non-coding RNAs and transcription factor networks[1][2].

Other names

RSF1HBXAPXAP8Rsf-1p325HBV pX-associated protein 8Hepatitis B virus X-associated proteinp325 subunit of RSF chromatin-remodeling complex

Not directly a drug target; however, mechanistically, RSF1 modulates DNA repair and transcription via interaction with histone-modifying enzymes (e.g., HDAC1) and by reading H2Aub marks[3][4].