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Remyelination via Secretion of Neurotrophic Factors
- Molecular classification
- Neurotrophic factors, Secreted proteins, Growth factors
01
Overview
This target represents a multifaceted approach aiming not at a single molecule but at harnessing an entire class—neurotrophins—to orchestrate cellular events required for effective CNS regeneration following demyelinating injury. It involves promoting remyelination by stimulating oligodendrocyte progenitor cells (OPCs) with secreted proteins such as BDNF, NGF, GDNF, IGF-1, and CNTF. These neurotrophic factors are secreted by glia (astrocytes/microglia) and neural progenitors/stem cells. Therapeutic strategies include direct protein delivery; gene/cell therapy; and immunomodulation.
- Other names
- Neurotrophic factor-mediated remyelinationNeurotrophin-induced remyelinationRemyelination through neurotrophic signaling
02
Mechanism of action
Stimulation of oligodendrocyte progenitor cell (OPC) proliferation, migration, and differentiation into mature oligodendrocytes; modulation of immune responses to create a pro-repair environment; enhancement of neuronal signaling to support glial-mediated repair processes.
03
Biological functions
RemyelinationOligodendrocyte differentiationAxonal survivalNeuroprotectionImmune modulationCell proliferationCell migration
04
Disease associations
Multiple sclerosisDemyelinating diseasesCNS injuryNeurodegenerative disease
05
Safety considerations
Blood-brain barrier penetrationOff-target effectsPleiotropic effects on various cell typesSustained expression at lesion sitesBalancing different neurotrophin types/receptors
06
Interacting drugs
Glatiramer acetate
2 more in the full profile.
07
Biomarkers
Myelin water fraction (MWF)Diffusion tensor imaging (DTI) metrics (e.g., fractional anisotropy)Visual evoked potentials (VEP)Optical coherence tomography (OCT) measurements of retinal nerve fiber layer thickness
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