Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Renal Dehydropeptidase I (None)
- Target
- None
- Molecular classification
- Enzyme, Metalloenzyme, Glycoprotein
01
Overview
Renal dehydropeptidase I (DPEP1) is a membrane-bound glycoprotein enzyme predominantly found in the kidney. Its primary function is to hydrolyze dipeptides and other compounds, including beta-lactam antibiotics like imipenem. Inhibition of DPEP1 by cilastatin is crucial for the therapeutic efficacy of imipenem.
- Other names
- Membrane dipeptidase (MDP)Dipeptidase 1 (DPEP1)DPEP1
02
Mechanism of action
Cilastatin inhibits renal dehydropeptidase I, preventing the breakdown of imipenem and other susceptible drugs.
03
Biological functions
Hydrolysis of dipeptidesLeukotriene D4 to leukotriene E4 conversionCystinyl-bis-glycine hydrolysisBeta-lactam antibiotic degradation
04
Disease associations
Infection
05
Safety considerations
Imipenem is rapidly inactivated by renal dehydropeptidase, requiring co-administration with cilastatin.
06
Interacting drugs
Imipenem
1 more in the full profile.
Beyond the preview
Go deeper on Renal Dehydropeptidase I (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Renal Dehydropeptidase I (None).