Renal protection

Renal protection" is not a molecule, receptor, or specific biological target. Instead, it is a therapeutic concept that encompasses various strategies, interventions, and drug targets aimed at preserving or improving kidney function and preventing the progression of kidney diseases such as chronic kidney disease (CKD) or diabetic kidney disease (DKD)[2][3][5]. Multiple molecular targets and pathways are implicated in achieving renal protection, including the renin–angiotensin–aldosterone system (targeted by ACE inhibitors and angiotensin receptor blockers), sodium-glucose cotransporter 2 (SGLT2), mineralocorticoid receptor, glucagon-like peptide-1 receptor, and others[2][3][5]. Because "renal protection" refers to an overall therapeutic goal and not to a single defined biological entity, it is not a canonical target and thus should not be listed as such in structured drug target databases.

Other names

Renal protectionRenoprotection

As 'Renal protection' is a therapeutic concept and not a single molecular target, it does not have a specific mechanism of action. Instead, it is achieved through various interventions and drug targets, such as modulation of the renin–angiotensin–aldosterone system, sodium-glucose cotransporter 2, mineralocorticoid receptor, and glucagon-like peptide-1 receptor, which individually have their own mechanisms to preserve kidney function.