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Renal Tubular Cell

Molecular classification: Epithelial Cell

Overview

Renal tubular cells are the specialized epithelial cells that line the renal tubules of the nephron, which is the functional unit of the kidney. These cells play a central role in maintaining fluid, electrolyte, and acid-base homeostasis by modifying filtrate from glomerular filtration into urine. They are not typically considered a direct therapeutic target themselves, but rather the site of action for many drugs affecting kidney function and are often monitored for signs of damage or dysfunction.

Biological functions

ReabsorptionSecretionElectrolyte BalanceAcid-Base RegulationUrine Concentration

Disease associations

Acute Kidney Injury (AKI)Chronic Kidney Disease (CKD)

Safety considerations

Susceptibility to ischemic injurySusceptibility to toxin-induced injury

Biomarkers

KIM-1NGALNAG

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