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Renal tubular reabsorption of calcium

Overview

"Renal tubular reabsorption of calcium" describes the coordinated physiological process by which the kidney's tubular system retrieves filtered calcium back into the circulation, predominantly via paracellular and transcellular pathways along the proximal tubule, thick ascending limb, distal convoluted tubule, and connecting tubule. Key proteins involved in this process include claudin family proteins (Claudin-2, -12, -16, -19, -14), calcium-sensing receptor (CaSR), TRPV5 and TRPV6 channels, calbindin-D28K, plasma membrane calcium ATPase, and the sodium-calcium exchanger NCX1, but the phrase itself does not denote a single, discrete druggable target[1][2][3][5][6][7][8].

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