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Renal tubule targets
- Molecular classification
- Transporter, Ion channel, Receptor, Enzyme
01
Overview
Renal tubule targets refer to a broad collection of proteins, including transporters, ion channels, and receptors, located within the epithelial cells of the renal tubules, such as the proximal tub}
- Other names
- Renal tubular targetsNephron targetsKidney tubule targetsRenal transport proteins
02
Mechanism of action
Inhibition of sodium-glucose cotransport (SGLT2), inhibition of sodium-potassium-chloride cotransport (NKCC2), inhibition of sodium-chloride cotransport (NCC), blockade of epithelial sodium channels (ENaC), antagonism of mineralocorticoid receptors (MR), and antagonism of vasopressin V2 receptors (V2R).
03
Biological functions
Ion transportWater reabsorptionGlucose reabsorptionAcid-base balanceEndocytosisHormone signaling
04
Disease associations
HypertensionDiabetes mellitusHeart failureChronic kidney diseaseEdemaElectrolyte disordersNephrotic syndrome
05
Safety considerations
Electrolyte imbalance (e.g., hypokalemia, hyponatremia)Dehydration and volume depletionAcute kidney injury (AKI)HypotensionEuglycemic ketoacidosis (with SGLT2 inhibitors)Urinary tract infections
06
Interacting drugs
Dapagliflozin
7 more in the full profile.
07
Biomarkers
Urinary sodiumFractional excretion of sodium (FENa)GlycosuriaUrinary albumin-to-creatinine ratio (UACR)Serum potassium levelsSerum creatinine
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