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Renal Urate Transporter
- Molecular classification
- Transporter, Membrane protein
01
Overview
Renal urate transporters are a group of membrane proteins in the kidney that regulate the reabsorption and secretion of uric acid. These transporters are primarily located in the proximal tubules of the nephron and play a critical role in maintaining uric acid homeostasis. Dysfunction or genetic variation in these proteins can lead to hyperuricemia or hypouricemia, contributing to gout or increased risk for kidney stones/crystal formation. Major renal urate transporters include URAT1, GLUT9, OAT1, OAT3, OAT4, OAT10, NPT4, and MRP4. URAT1 is a major drug target, with inhibitors like lesinurad developed for treatment-resistant gout.
- Other names
- Urate transporterUric acid transporterRenal urate channel
02
Mechanism of action
Inhibition of renal urate reabsorption
03
Biological functions
Urate transportUric acid homeostasisRenal reabsorptionRenal secretion
04
Disease associations
GoutHyperuricemiaHypouricemiaKidney stonesCrystal nephropathy
05
Safety considerations
Drug interactionsAdverse effects related to altered urate levels
06
Interacting drugs
Lesinurad
07
Biomarkers
Serum urate levels
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