Renin pseudogene

The renin pseudogene (ENSG00000226973) is a nonfunctional genomic locus that shows sequence homology to the functional human renin gene (REN) but contains one or more mutations that prevent it from producing active renin protein. Pseudogenes like this arise through gene duplication or retrotransposition events followed by disabling mutations, such as frameshifts or premature stop codons. While some pseudogenes can be transcribed and might influence gene expression through regulatory RNAs, most—including the renin pseudogene—lack known physiological or pathological roles and are not drug targets[1][2][3][4][5]. This entry should not be confused with the functional Renin protein, a clinically relevant target in hypertension and cardiovascular diseases. Key points: - The renin pseudogene is *not* a therapeutic target or druggable entity. - It is a nonfunctional DNA segment, not a protein-coding gene, enzyme, receptor, or transporter. - Any reference to therapeutic modulation or biomarker status for this locus is incorrect in biomedical and clinical contexts.

Other names

Renin (REN) pseudogene