Reparative Dentin Formation

Reparative dentin formation (reparative dentinogenesis) is the process by which new dentin is generated by odontoblast-like cells derived from dental pulp stem cells after severe injury to the tooth that breaches the odontoblast layer, such as caries or trauma. This tertiary dentin is often less organized, resembling bone-like tissue (osteodentin), and forms as an attempt to restore the integrity of the pulp and dentin-pulp complex. Various bioactive molecules (e.g., BMPs, TGF-β, Wnt/β-catenin modulators), drugs (calcium hydroxide, MTA, apigenin), and regenerative therapies stimulate this process. While it is therapeutically leveraged for dental repair, "Reparative Dentin Formation" is not a molecular target or receptor, but rather a physiological response pathway involving multiple cell types and signaling cascades[1][2][4][5][6][7].

Other names

Reparative dentinogenesistertiary dentin formation

Induction of odontoblast-like cell differentiation from dental pulp stem cells (DPSCs); Stimulation of mineralization and extracellular matrix formation; Activation of key signaling pathways (BMP, TGF-β, Wnt/β-catenin)