Repetin (RPTN)

Repetin is a structural protein expressed in the human epidermis, encoded by the RPTN gene. It is a member of the S100 fused-type protein family and contains an EF-hand calcium-binding domain. Repetin is localized in the epidermal differentiation complex and is involved in the formation of the cornified cell envelope—a critical component of skin barrier function. It is reversibly calcium-binding and a key extracellular matrix protein that contributes to the mechanical stability and structural integrity of terminally differentiated keratinocytes. Disease associations are limited to genetic skin disorders involving abnormal keratinization, such as ichthyosis vulgaris and autosomal recessive congenital ichthyosis. Repetin is neither a classical receptor nor a typical drug target, but its function is crucial for epidermal differentiation and protection.

Other names

RepetinRPTNFLJ39117Intermediate filament-associated proteinRPTN_HUMANQ6XPR3

Not applicable. No drugs or therapeutic agents are known to act directly on repetin.